RESEARCH
Personalized medicines and lower-cost drug development are two of the practical benefits of mapping the 3 billion chemical base pairs in the human genome. The human genome project is just one of the groundbreaking research initiatives that involved researchers from the New York State Center of Excellence in Bioinformatics & Life Sciences (CoE). By merging high-performance computing and high-end visualization with genomics, proteomics and bioimaging, the CoE has created a unique and powerful combination of technologies and research expertise that fosters advancements in science and health care. This approach complements the critical mass of world-class researchers, in both basic and applied sciences, who already provide industry partners with a wide scope of potential new leads, technologies, and discoveries through the CoE's primary research institutions: the University at Buffalo, Roswell Park Cancer Institute and the Hauptman-Woodward Medical Research Institute:
The CoE faculty include over 100 biological, physical and computational scientistsfrom interdisciplinary laboratories involved with the COE's translational research efforts representing broad capabilities and core research groups.
Research Capabilities
- Bioengineering
- Bioimaging
- Bioinformatics
- Cardiology
- Disease Modeling
- Epidemiology
- Genetics
- Genomics
- High Performance Computing
- Immunotherapy
- Neurology
- Oncology
- Oral Biology
- Structural Biology
- Pharmacokinetics & Pharmacodynamics
- Pharmacology
- Proteomics
Core Research Groups
- Cancer Biology
- Cardiovascular Disease
- Neurodegenerative Disease
- Pathogens & Biodefense
- Translational Pharmacology
Research Highlight
Landmark Trial to Evaluate Cardioprotective Properties of Insulin
11/09/07 - BUFFALO, N.Y. -- The ability of insulin to limit heart-tissue damage during a heart attack will be tested in a landmark clinical trial led by Paresh Dandona, M.D., Ph.D. Approximately 600 patients at 90 centers in the U.S. and Latin America will be recruited to participate in the two-year INTENSIVE (Intensive Insulin Therapy and Size of Infarct as a Validated Endpoint by Cardiac MRI) trial. Patients in the trial, which is funded by sanofi-aventis, will be treated with two forms of insulin -- insulin glargine and insulin glulisine.
Kaleida Health's Diabetes-Endocrine Center of Western New York, which Dandona directs, will be one of the vanguard centers. The center's research facility, located in UB's New York State Center of Excellence in Bioinformatics and Life Sciences, will serve as the core laboratory. The trial is based on a pilot study conducted by the diabetes center, which documented that insulin, used to treat and control type 1 and type 2 diabetes, was also cardioprotective. "The markers of myocardial damage that we measured were reduced significantly," said Dandona. "We are excited to learn more about the potential cardioprotective benefits we may discover with insulin. We think insulin will improve blood flow during a heart attack and help limit damage to heart tissue." ...[Read On...]
Featured Researcher
Paresh Dandona, MD.,Ph.D.
UB Distinguished Professor; Clinical Professor
Medicine; Pharmacology And Toxicology
Paresh Dandona, M.D., Ph.D., is a University at Buffalo Distinguished Professor in the departments of Medicine and Pharmacology and Toxicology in the UB School of Medicine and Biomedical Sciences. Dr. Dandona's research focus is endocrinology, diabetes and metabolism with interests in specific areas such as vascular cell reactivity encompassing platelet function, endothelial function, monocyte/macrophage function and the interactions between them.
[ Dr. Paresh Dandona's Website]
News
Reception to Honor UB's Inventors, Entrepreneurs
05/04/2008 - BUFFALO, N.Y. -- The University at Buffalo and its Office of Science, Technology Transfer and Economic Outreach (STOR) will recognize the research and commercialization achievements of faculty members at the annual Inventors and Entrepreneurs Reception to be held from 4-6 p.m. May 5 in The Buffalo Club, 388 Delaware Ave...[Read On]
Study Describes Mechanism Linking Alcohol with Risk of Breast Cancer
04/30/2008 - BUFFALO, N.Y. -- The known association of alcohol consumption with an increased risk of breast cancer has been linked by researchers at the University at Buffalo to a process that causes genes that promote normal cell growth to produce proteins that precipitate unregulated cell growth, an action known as hypermethylation...[Read On...]
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Events
May 6 - Dr. Austin Clean Room Program
Don’t miss the opportunity to hear one of the world’s foremost Cleanroom and Contamination Control Experts. Dr. Austin has published six textbooks on clean rooms and personally authored each of the clean room standards adopted by ISO. This program will take place from 2-6pm Roswell Park Cancer Institute, Center for Genetics & Pharmacology, Zebro Room, 701 Ellicott Street, Buffalo, NY. Register at www.thepartnership.org/events. See flyer for more information. 
May 8 – HWI Seminar Series
Please join Dr. Michael Rossman from Purdue University for a presentation on “Symmetry and asymmetry in the control of viral assembly, maturation and infection”. Program begins at 2:30pm with a reception to follow. Series is held at the Hauptman-Woodward Institute 700 Ellicott Street, Buffalo, NY 14203.
To view the complete list of events and event details, please visit our Events page
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